Product Name :
PAF-R Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
OTTHUMP00000004041 antibody OTTMUSP00000010350 antibody PAF R antibody PAF receptor antibody PAF-R antibody PAFr antibody Platelet activating factor receptor antibody Platelet-activating factor receptor antibody PTAFR antibody PTAFR_HUMAN antibody 展开
Function :
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants.
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
The antiserum was produced against synthesized peptide derived from human PTAFR.Formula of Caffeine Impurity 7 AA range:194-243
Species reactivity:
Human, Mouse, Rat
Verify application:
IF
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.82979-45-1 web Aliquot store at -20℃ or -80℃.PMID:33730321 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
Positive control :
Brain,Cervix carcinoma,Fetal liver,Granulocyte,Heart ventricle,Leuk