Product Name :
U1A Recombinant Rabbit Monoclonal Antibody [JB33-48]
Predicted band size :
Observed band size :
Synonyms:
fc19d01 antibody Mud1 antibody small nuclear ribonucleoprotein polypeptide A antibody snRNP A antibody snRNP protein A antibody SNRPA antibody SNRPA_HUMAN antibody U1 small nuclear ribonucleoprotein A antibody U1 small nuclear RNP specific A antibody U1 snRNP A antibody 展开
Function :
SNRPA (small nuclear ribonucleoprotein polypeptide A), also known as U1A (U1 snRNP protein A), is a component of the RNA spliceosome, a complex of proteins that are required for the precise excision of introns from pre-messenger RNA (pre-mRNA). Localizing to the nucleus, SNRPA contains two RRM (RNA recognition motif) domains, namely RRM1 and RRM2, and RRM1 specifically associates with the stem loop II of U1 snRNA (small nuclear RNA). In addition to functioning as a component of the U1 snRNP, SNRPA negatively regulates polyadenylation of SNRPA pre-mRNA, thereby negatively regulating itself. By inhibiting the addition of a polyA tail that would allow the pre-mRNA to mature, SNRPA causes the nuclear exosome degradation of the SNRPA pre-mRNA. At least 16% of cellular SNRPA also functions in an snRNP-free form (SF-A) that complexes with a group of non-snRNP proteins.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Recombinant protein within Human U1A aa 1-96 / 282.
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IF-Cell, IF-Tissue, IHC-P, IP
Coupling :
unconjugated
Clone number:
JB33-48
RRID:
AB_3070802
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃. Avoid repeated freeze / thaw cycles.Silver(I) carbonate uses
Storage buffer solution:
1*TBS (pH7.98730-77-9 structure 4), 0.PMID:33734482 05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
Predicted band size: 31 kDa
Positive control :
Rat brain tissue lysate, K562 cell lysate, A431 cell lysate, mouse kidney tissue lysate, A549 cell lysates, 293T, SH-SY5Y, SiHa, human lung carcinoma tissue, mouse liver tissue.