Vironmental Health Sciences Core Center (funded by National Institute of Environmental Well being Sciences, P30 ES004184) in the University of Wisconsin Milwaukee. Dr. Phani Kumar Pullela is gratefully acknowledged for providing the synthesized F-E2 tracer. High-resolution mass spectra were obtained at the COSMIC lab at Old Dominion University.References and notes1. Manas ES, Xu ZB, Unwalla RJ, Somers WS. Structure. 2004; 12:2197. [PubMed: 15576033] two. Levin ER. Mol Endocrinol. 2005; 19:1951. [PubMed: 15705661] 3. Li X, Huang J, Yi P, Bambara RA, Hilf R, Muyan M. Mol Cell Biol. 2004; 24:7681. [PubMed: 15314175] 4. Brzozowski AM, Pike ACW, Dauter Z, Hubbard RE, Bonn T, Engstrom O, Ohman L, Greene GL, Gustafsson JA, Carlquist M. Nature. 1997; 389:753. [PubMed: 9338790] five. Payne J, Scholz M, Kortenhamp A. Environ Health Perspect. 2001; 109:391. [PubMed: 11335188] six. Blair RM, Fang H, Branham WS, Hass BS, Dial SL, Moland CL, Tong W, Shi L, Perking R, Sheehan DM. Toxicol Sci. 2000; 54:138. [PubMed: 10746941] 7. Deroo BJ, Korach KS. J Clin Invest. 2006; 116:561. [PubMed: 16511588] eight. Colborn T, Saal FS, Soto AM. Environ Wellness Perspect. 1993; 101:378. [PubMed: 8080506] 9. Brody JG, Rudel RA. Environ Wellness Perspect. 2003; 111:1007. [PubMed: 12826474] 10. Tice, R. National Toxicology Program. National Institute of Environmental Overall health Sciences. NIH, U.S. Dept. of Overall health and Human Services; 2001. Biomolecular Screening Branch. July 5, 2013 (http://niehs.nih.gov/research/atniehs/labs/bmsb/index.cfm) 11. Nasir MS, Jolley ME. Comb Chem Higher Throughput Screening. 1999; two:177. 12. Burke TJ, Loniello KR, Beebe JA, Ervin KM. Comb Chem High Throughput Screening. 2003; 6:183. 13. Ohno K, Fukushima T, Santa T, Waizumi N, Tokuyama H, Maeda M, Imai K. Anal Chem. 2002; 74:4391. [PubMed: 12236347] 14. Suzuki S, Ohno K, Santa T, Imai K. Anal Sci. 2003; 19:1103. [PubMed: 12945660] 15.tBuXPhos Pd G3 web Parker GJ, Law TL, Lenoch FJ, Bolger RE.5-Bromo-6-fluorobenzo[d]thiazol-2-amine structure J Biomol Screen.PMID:33723800 2000; five:77. [PubMed: 10803607] 16. Costache AD, Pullela PK, Kashi P, Tomasiewicz H, Sem DS. Mol Endocrinol. 2005; 19:2979. [PubMed: 16081519]Bioorg Med Chem. Author manuscript; accessible in PMC 2015 January 01.McCullough et al.Page17. Bolger R, Wiese TE, Ervin K, Nestich S, Checovich W. Environ Overall health Perspect. 1998; 106:551. [PubMed: 9721254] 18. Shoichet BK. Nature. 2004; 432:862. [PubMed: 15602552] 19. Irwin JJ, Shoichet BK. J Chem Inf Model. 2005; 45:177. [PubMed: 15667143] 20. Cavasotto CN, Orry AJW. Curr Best Med Chem. 2007; 7:1006. [PubMed: 17508934] 21. Suresh PS, Kumar A, Kumar R, Sihn VP. J Mol Graphics Modell. 2008; 26:845. 22. Cross JB, Thompson DC, Rai BK, Baber JC, Fan KY, Hu Y, Humblet C. J Chem Inf Model. 2009; 49:1455. [PubMed: 19476350] 23. De Riccardis F, Meo D, Izzo I, Di Filippo M, Casapullo A. Eur J Org Chem. 1998:1965. 24. Lam HYP, Begleiter A, Goldenberg GJ. J Med Chem. 1979; 22:200. [PubMed: 106120] 25. Li, PK.; Murakata, C.; Akinaga, S. US Patent. 6,288,050, 2001.. 26. He Z, Donaldson WA, Yi CS. Org Lett. 2003; 5:1567. [PubMed: 12713325] 27. Frigoli M, Mehl GH. Eur J Org Chem. 2004:636.DeOrazio, RJ.; Nikam, SS.; Scott, IL.; Sherer, BA.; Smart, LD. PCT Int Appl WO. 01/81295 A1. 2001. 28. Indigo Biosciences. Human Estrogen Receptor Technical Manual. 29. Pandey RK, Wang L, Wallock NJ, Lindeman S, Donaldson WA. J Org Chem. 2008; 73:7236. [PubMed: 18712926] 30. van Lipzig MMH, ter Laak AM, Jongegan A, Vermeulen NPE, Wamelink M, Geerke D, Meerman JHN. J Med Chem. 2004; 47:1018. [PubMed: 14761204] 31. Miteva M.