Product Name :
2-Amino-9H-pyrido[2,3-b]indole (CAS 26148-68-5)
Synonym :
1H-Pyrido[2,3-b]indol-2-amine; 2-Amino-α-carboline
Application :
2-Amino-9H-pyrido[2,3-b]indole is a pyrolysate
CAS:
26148-68-5
Purity:
Molecular Weight:
183.2
Formula :
C11H9N3
Physical state:
Solid
solubility :
Shipping Condition :
Store at -20° C
Melting point:
194-196° C (dec.)
SMILES:
C1=CC=C2C(=C1)C3=C(N2)N=C(C=C3)N
References:
:The food mutagen 2-amino-9H-pyrido[2,3-b]indole (AalphaC) but not its methylated form (MeAalphaC) increases intestinal tumorigenesis in neonatally exposed multiple intestinal neoplasia mice. | Steffensen, IL., et al. 2002. Carcinogenesis. 23: 1373-8. PMID: 12151357Excretion of metabolites in urine and faeces from rats dosed with the heterocyclic amine, 2-amino-9H-pyrido[2,3-b]indole (AalphaC). | Frederiksen, H. and Frandsen, H. 2004. Food Chem Toxicol. 42: 879-85. PMID: 15110096Tobacco smoking and urinary levels of 2-amino-9H-pyrido[2,3-b]indole in men of Shanghai, China. | Turesky, RJ., et al. 2007. Cancer Epidemiol Biomarkers Prev. 16: 1554-60. PMID: 17684128UDP-glucuronosyltransferase-mediated metabolic activation of the tobacco carcinogen 2-amino-9H-pyrido[2,3-b]indole. | Tang, Y., et al. 2012. J Biol Chem. 287: 14960-72. PMID: 22393056DNA adduct formation of 2-amino-9H-pyrido[2,3-b]indole and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline in mouse liver and extrahepatic tissues during a subchronic feeding study.Azido-PEG2-C2-amine In stock | Tang, Y., et al. 2013. Toxicol Sci. 133: 248-58. PMID: 235353642-Amino-9H-pyrido[2,3-b]indole (A alpha C) Adducts and Thiol Oxidation of Serum Albumin as Potential Biomarkers of Tobacco Smoke. | Pathak, KV., et al. 2015. J Biol Chem. 290: 16304-18. PMID: 25953894Measurement of the Heterocyclic Amines 2-Amino-9H-pyrido[2,3-b]indole and 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Urine: Effects of Cigarette Smoking. | Konorev, D., et al. 2015. Chem Res Toxicol. 28: 2390-9. PMID: 26574651Effect of Cytochrome P450 Reductase Deficiency on 2-Amino-9H-pyrido[2,3-b]indole Metabolism and DNA Adduct Formation in Liver and Extrahepatic Tissues of Mice. | Turesky, RJ., et al. 2015. Chem Res Toxicol. 28: 2400-10. PMID: 26583703Metabolism of the Tobacco Carcinogen 2-Amino-9H-pyrido[2,3-b]indole (A alpha C) in Primary Human Hepatocytes.152754-55-7 Formula | Bellamri, M.PMID:33588963 , et al. 2017. Chem Res Toxicol. 30: 657-668. PMID: 27976871Quantification of Hemoglobin and White Blood Cell DNA Adducts of the Tobacco Carcinogens 2-Amino-9H-pyrido[2,3-b]indole and 4-Aminobiphenyl Formed in Humans by Nanoflow Liquid Chromatography/Ion Trap Multistage Mass Spectrometry. | Cai, T., et al. 2017. Chem Res Toxicol. 30: 1333-1343. PMID: 28493705Effects of 2-amino-9H-pyrido[2,3-b]indole (A alpha C) metabolic bio-activation on oxidative DNA damage in human hepatoma G2 (HepG2) cells. | Liu, X., et al. 2018. Toxicol Mech Methods. 28: 230-237. PMID: 29022416Bioactivation of the tobacco carcinogens 4-aminobiphenyl (4-ABP) and 2-amino-9H-pyrido[2,3-b]indole (A alpha C) in human bladder RT4 cells. | Bellamri, M., et al. 2019. Arch Toxicol. 93: 1893-1902. PMID: 31203411Metabolic activation of 2-amino-9H-pyrido[2,3-b]indole by rat-liver microsomes. | Niwa, T., et al. 1982. Mutat Res. 95: 159-70. PMID: 6750381