PDGF Receptor alpha Rabbit Polyclonal Antibody

Function :
Platelet derived growth factor (PDGF) is a mitogen for mesenchyme- and gliaderived cells. PDGF consists of two chains, A and B, which dimerize to form functionally distinct isoforms, PGDF-AA, PDGF-AB and PDGF-BB. These three isoforms bind with different affinities to two receptor types, PDGFR-α and -β, which are endowed with protein tyrosine kinase domains.Price of 939793-16-5 PDGFR-α can bind to both A and B subunits of PDGF, while PDGFR-β can only bind the B subunit. Ligand binding promotes either homo- or heterodimerization of the PDGF receptors in a specific manner. PDGF-AA induces the dimerization of two α receptors, PDGF-AB induces dimerization of αα and αβ, and PDGF-BB induces the formation of three types of dimers, αα, αβ and ββ. The genes encoding PDGFR-α and -β map to human chromosome 4q12 and 5q31-32, respectively. Translocation of the PDGFR-β gene with the Tel gene is linked with chronic myelomonocytic leukemia (CMML), a myelodysplastic syndrome, and demonstrates the oncogenic potential of the PDGF receptors.