Product Name :
SACS Rabbit Polyclonal Antibody
Predicted band size :
Observed band size :
Synonyms:
DnaJ homolog subfamily C member 29 antibody DNAJC29 antibody SACS antibody SACS_HUMAN antibody Sacsin antibody Spastic ataxia of Charlevoix-Saguenay antibody
Function :
This gene encodes the sacsin protein, which includes a UbL domain at the N-terminus, a DnaJ domain, and a HEPN domain at the C-terminus. The gene is highly expressed in the central nervous system, also found in skin, skeletal muscles and at low levels in the pancreas. This gene includes a very large exon spanning more than 12. 8 kb. Mutations in this gene result in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS), a neurodegenerative disorder characterized by early-onset cerebellar ataxia with spasticity and peripheral neuropathy. The authors of a publication on the effects of siRNA-mediated sacsin knockdown concluded that sacsin protects against mutant ataxin-1 and suggest that “the large multi-domain sacsin protein is able to recruit Hsp70 chaperone action and has the potential to regulate the effects of other ataxia proteins” (Parfitt et al.N3-PEG3-C2-NHS ester Formula PubMed: 19208651).Price of 5-Boronopicolinic acid
Antibody Type:
Rabbit Polyclonal Antibody
Immunogen :
Synthesized peptide derived from human protein .PMID:33590949 at AA range: 4291-4340
Species reactivity:
Human, Mouse
Verify application:
IHC-P
Coupling :
unconjugated
Clone number:
RRID:
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing. Aliquot store at -20℃ or -80℃. Avoid repeated freeze / thaw cycles.
Storage buffer solution:
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Subtype:
IgG
Purification method :
Immunogen affinity purified.
ELTSA :
Molecular weight :
503 kDa
Positive control :
Astrocyte,Brain,Fetal liver,Uterine endothelium,